5-alpha-reductase inhibitors may be used in the treatment of benign prostatic hyperplasia ( enlarged prostate gland) and male-pattern hair loss (androgenic alopecia ). They are not approved for the prevention of prostate cancer.
5 alpha reductase inhibitors e.g. finasteride reduce prostate cancer risk but may increase the risk of high-grade disease in men who are undergoing regular screening for prostate cancer using prostate specific antigen and digital rectal examination
Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors. Screening for the early detection of prostate cancer based on PSA is useful and reduces mortality,on the contrary of what widespread and propagated in the last years.. Worse Prostate Cancer Outcomes With 5-Alpha-Reductase.
Men treated with medications for symptoms of benign prostatic hyperplasia (BPH) experienced a two-year delay in diagnosis of their prostate cancer and were twice as. care teams and patients that.
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Association of Treatment With 5-Reductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer.. The association of 5-ARIs with detection of prostate cancer in a psa-screened population remains unclear.. diagnosis and worse cancer-specific outcomes in men with prostate cancer.
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Often life-altering, PFS is characterized by devastating sexual, neurological, and physical side effects that persist in men who have taken the 5-alpha reductase type II enzyme inhibitor finasteride. Finasteride is prescribed for the treatment of hair loss under the brand name Propecia (and generics) and for the treatment of enlarged prostate.
Response: 5 alpha-reductase inhibitors (5aris) are often used for the management of lower urinary tract symptoms in men. Two prior clinical trials found 5ARIs also reduced the risk of prostate cancer, but there was an increase in more aggressive (Gleason 7-10) cancers among the men who were diagnosed.
Treatment with 5-alpha-reductase inhibitors (5-ARIs) is associated with worse mortality in prostate cancer, report findings from Veterans Affairs electronic health records.Dr. Brent S. Rose, from the University of California, San Diego in La Jolla, said, "5-ARIs, like finasteride and dutasteride, reduce the PSA by about 50%.
Role of 5 alpha-reductase inhibitors in the management of prostate cancer Article Literature Review (PDF Available) in Clinical Interventions in Aging 1(4):425-31 February 2006 with 437 Reads
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Men who take 5-alpha reductase inhibitors (5-ARI) for benign prostatic. inhibitors with time to diagnosis and mortality in prostate cancer.
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